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Ago 26, 2021

KiteLock 4%: the solution to the "triple threat"

A single device, three simultaneous actions, to reduce risks and complications for patients requiring central venous access devices.

KiteLock is Delta Med's lock solution for catheters, designed to effectively combat the "triple threat" represented by the possible formation of clots, biofilm and microorganisms inside CVCs.

Several sector studies have already shown how useful it can be reducing bacteremia and infections with a practical and safe disposable solution. Let's see, in detail, what it is.

The triple action of KiteLock™

Simply eliminating the risk of clots in CVCs is not enough to avoid patient complications. Within 7 days, in fact, the devices can be colonized by microorganisms incorporated in the biofilm, creating the conditions for serious infections.

KiteLock™ is a transparent, colorless, single-use solution containing a mixture of tetrasodium edetate and trisodium edetate. This allows it to act in three directions, thanks to an action:

  • anticoagulant;
  • antibacterial;
  • anti-biofilm.

Apyrogenic and aqueous, this solution contains no preservatives, no alcohol and no latex. Furthermore, since Tetrasodium EDTA is a non-antibiotic agent, it does not even contribute to antibiotic resistance (an issue not to be underestimated, as described in this article).

KiteLock™ can maintain patency within the central venous access device. In addition, clinical studies have shown an 87% reduction in the rate of bacterial colonization in patients with dialysis catheters.

Safety and efficacy of Tetrasodium EDTA

Unlike common doses of edetate used in chelating therapies, the concentration of KiteLock™ 4% does not expose the patient to physiological, pharmacological, therapeutic or adverse effects.

Even in the most unlikely of scenarios, i.e. considering a 3 mL flush of KiteLock, it would require a 15 mL dilution of blood in order not to disturb the blood pH. Considering that there are at least 90 mL of blood per second passing through the heart, the margin of safety is 6 times greater.

Furthermore, the chelating action of EDTA also has several effects on the bacteria that can form in the internal lumen of the catheter. Some of the main ones are:

  • damage to the outer membrane;
  • bacterial starvation;
  • chromosomal and RNA activity;
  • anti-adhesion surface and disintegrating effect;
  • dispersion of biofilm microbes;
  • inhibition of metalloproteinases;
  • local pH increase.

KiteLock™ 4% has been successfully tested with materials such as Silastic and polyurethane catheters (compliant with industry standards).

If you are interested in learning more about the details and benefits of this catheter lock solution, contact us here for more information from one of our professionals.

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